In the Great War the Regiment saw action in the retreat from Mons, the Battle of the Marne and at Langemark, Aisne, Gheluvelt and Ypres in 1914. Nonne Bosschen, Festubert and Gallipoli in 1915, and Loos and the Battle of the Somme in 1916.
In 1917 it saw involvement in actions at Bagentin, Delville Wood, Le Transloy, Arras, Ypres Menin Road, Polygon Wood, and Passchendale. The regiment then fought at Cambrai, Lys, Bailleul, Kemmel, Hindenburg Line, St. Quentin Canal and Selle in 1918.
Members of the Regiment won nine Victoria Crosses, 70 Distinguished Service Orders (and 12 bars), 288 Military Crosses ( and 36 bars), 227 Distinguished Conduct Medals (and 8 bars).
In December 1918 they were used to suppress the Taranto Revolt, executing one of the rebels by firing squad.